Pathomechanismen und Signaturen im Langzeitverlauf der Psychose

30.07.2019

2019

Kálmán J, Papiol S, Forstner AJ, Heilbronner U, Degenhardt F, Strohmaier J, Adli M, Adorjan K, Akula N, Alda M, Anderson-Schmidt H, Andlauer TFM, Anghelescu I, Ardau R, Arias B, Arolt V, Aubry J, Backlund L, Bartholdi K, Bauer M, Baune BB, Becker T, Bellivier F, Benabarre A, Bengesser S, Bhattacharjee AKumar, Biernacka JM, Birner A, Brichant-Petitjean C, Budde M, Cervantes P, Chilotti C, Cichon S, Clark SR, Colom F, Comes AL, Cruceanu C, Czerski PM, Dannlowski U, Dayer A, Del Zompo M, DePaulo JRaymond, Dietrich DE, Ètain B, Ethofer T, Falkai P, Fallgatter AJ, Figge C, Flatau L, Folkerts H, Frisen L, Frye MA, Fullerton JM, Gade K, Gard S, Garnham JS, Goes FS, Grigoroiu-Serbanescu M, Gryaznova A, Hake M, Hauser J, Herms S, Hoffmann P, Hou L, Jäger M, Jamain S, Jímenez E, Juckel G, Kahn J, Kassem L, Kelsoe J, Kittel-Schneider S, Kliwicki S, Klöhn-Saghatolislam F, Koller M, König B, Konrad C, Lackner N, Laje G, Landén M, Lang FU, Lavebratt C, Leboyer M, Leckband SG, Maj M, Manchia M, Martinsson L, McCarthy Mj, McElroy SL, McMahon FJ, Mitchell PB, Mitjans M, Mondimore FM, Monteleone P, Nieratschker V, Nievergelt CM, Novák T, Ösby U, Pfennig A, Potash JB, Reich-Erkelenz D, Reif A, Reimer J, Reininghaus EZ, Reitt M, Ripke S, Rouleau GA, Rybakowski J, Schalling M, Scherk H, Schmauss M, Schofield PR, Schubert KOliver, Schulte EC, Schulz S, Senner F, Severino G, Shekhtman T, Shilling PD, Simhandl C, Slaney CM, Spitzer C, Squassina A, Stamm T, Stegmaier S, Stierl S, Stopkova P, Thiel A, Tighe SK, Tortorella A, Turecki G, Vieta E, Veeh J, von Hagen M, Wigand ME, Wiltfang J, Witt SH, Wright A, Zandi PP, Zimmermann J, Nöthen MM, Rietschel M, Schulze TG.
Investigating polygenic burden in age at disease onset in bipolar: Findings from an international multicentric study.
Bipolar Disord
2019 21(1): 68-75 [Epub ahead of print: 2018-06-28], IF: 3.940

Budde M, Friedrichs S, Alliey-Rodriguez N, Ament S, Badner A, Berrettini W, Bloss CS, Byerley W, Cichon S, Comes AL, Coryell W, Craig DW, Degenhardt F, Edenberg HJ, Foroud T, Forstner AJ, Frank J, Gerson ES, Goes FS, Greenwood TA, Guo Y, Hipolito M, Hood L, Keating BJ, Koller DL, Lawson WB, Liu C, Mahon PB, McInnis MG, McMahon FJ, Meier SM, Mühleisen TW, Murray SS, Nievergelt CM, Nurnberger JJr, Nwulia EA, Potash JB, Quarless D, Rice J, Roach JC, Scheftner WA, Schork NJ, Shekhtman T, Shilling PD, Smith EN, Streit F, Strohmaier J, Szelinger S, Treutlein J, Witt SH, Zandi PP, Zhang P, Zöllner S, Bickeböller H, Falkai P, Kelsoe J, Nöthen MM, Rietschel M, Schulze TG, Malzahn D.
Efficient region-based test strategy uncovers genetic risk factors for functional outcome in bipolar disorder
Eur Neuropsychopharmacol
2019 29(1): 156-170 [Epub ahead of print: 2018-11-21], IF: 4.369

Comes AL, Senner F, Budde M, Adorjan K, Anderson-Schmidt H, Andlauer TFM, Gade K, Hake M, Heilbronner U, Kálmán J, Reich-Erkelenz D, Klöhn-Saghatolislam F, Schaupp SK, Schulte EC, Juckel G, Dannlowski U, Schmauss M, Zimmermann J, Reimer J, Reininghaus EZ, Anghelescu I, Arolt V, Baune BB, Konrad C, Thiel A, Fallgatter AJ, Nieratschker V, Figge C, von Hagen M, Koller M, Becker T, Wigand ME, Jäger M, Dietrich DE, Stierl S, Scherk H, Spitzer C, Folkerts H, Witt SH, Degenhardt F, Forstner AJ, Rietschel M, Nöthen MM, Wiltfang J, Falkai P, Schulze TG, Papiol S.
The genetic relationship between educational attainment and cognitive performance in major psychiatric disorders
Transl Psychiatry
2019 9(1): 210 [Epub ahead of print: ], IF: 4.961

Anderson-Schmidt H, Gade K, Malzahn D, Papiol S, Bokelmann K, Heilbronner U, Reich-Erkelenz D, Adorjan K, Kálmán J, Senner F, Comes AL, Flatau L, Gryaznova A, Hake M, Reitt M, Schmauss M, Juckel G, Reimer J, Zimmermann J, Figge C, Reininghaus EZ, Anghelescu I, Konrad C, Thiel A, von Hagen M, Koller M, Stierl S, Scherk H, Spitzer C, Folkerts H, Becker T, Dietrich DE, Andlauer TFM, Degenhardt F, Nöthen MM, Witt SH, Rietschel M, Wiltfang J, Falkai P, Schulze TG.
The influence of religious activity and polygenic schizophrenia risk on religious delusions in schizophrenia
Schizophrenia Res
2019 210: 255-61 [Epub ahead of print: 2019-08-15], IF: 4.748

Kálmán J, Bresnahan M, Schulze TG, Susser E.
Predictors of persisting psychotic like experiences in children and adolescents: A scoping review.
Schizophrenia Res
2019 209: 32-9 [Epub ahead of print: 2019-08-20], IF: 4.748

2018

Yasmeen S, Burger P, Friedrichs S, Papiol S, Bickeböller H.
Relating Drug Response to Epigenetic and Genetic Markers Using a Region-Based Kernel Score Test
BMC Proc
2018 12(Suppl 9): 255-8 [Epub ahead of print: 2018-09-19], IF: 0.000

Budde M, Anderson-Schmidt H, Gade K, Reich-Erkelenz D, Adorjan K, Kálmán J, Senner F, Papiol S, Andlauer TFM, Comes AL, Schulte EC, Klöhn-Saghatolislam F, Gryaznova A, Hake M, Bartholdi K, Flatau L, Reitt M, Quast S, Stegmaier S, Meyers M, Emons B, Haußleiter IS, Juckel G, Nieratschker V, Dannlowski U, Schmauss M, Zimmermann J, Reimer J, Schulz S, Wiltfang J, Reininghaus EZ, Anghelescu I, Arolt V, Baune BB, Konrad C, Thiel A, Fallgatter AJ, Figge C, von Hagen M, Koller M, Lang FU, Wigand ME, Becker T, Jäger M, Dietrich DE, Stierl S, Scherk H, Spitzer C, Folkerts H, Witt SH, Degenhardt F, Forstner AJ, Rietschel M, Nöthen MM, Falkai P, Schulze TG, Heilbronner U.
A longitudinal approach to biological psychiatric research: the PsyCourse study.
Am J Med Genet
2018 180(2): 89-102 [Epub ahead of print: 2017-10-27], IF: 3.016

Raabe FJ, Galinski S, Papiol S, Falkai P, Schmitt A, Rossner MJ.
Studying and modulating schizophrenia-associated dysfunctions of oligodendrocytes with patient-specific cell systems.
NPJ Schizophr
2018 4(1): 23 [Epub ahead of print: 2018-11-19], IF: 0.000

Budde M, Schulze TG, Schaupp SK.
Let's Talk about the Association between Schizophrenia Polygenic Risk Scores and Cognition in Patients and the General Population: A Review
J Psychiatry Brain Sci
2018 3(6): 12 [Epub ahead of print: 2018-12-21], IF:

Comes AL, Papiol S, Müller T, Geyer P, Mann M, Schulze TG.
Proteomics for blood biomarker exploration of severe mental illness: pitfalls of the past and potential for the future.
Transl Psychiatry
2018 8(1): 160 [Epub ahead of print: 0000-00-00], IF: 4.961

2017

Senner F, Schulze TG.
Environmental factors, life events, and trauma in the course of bipolar disorder.
Psychiatry Clin Neurosci
2017 71(1): 6-17 [Epub ahead of print: 2016-09-21], IF: 2.063

Liu Y, Cui L, Schwarz MK, Dong Y, Schlüter O.
Adrenergic gate release for spike timing-dependent synaptic potentiation.
Neuron
2017 93: 1-15 [Epub ahead of print: 2017-01-18], IF: 13.974

Shukla A, Beroun A, Panopoulou M, Neumann PA, Grant SGN, Olive FM, Dong Y, Schlüter O.
Calcium-permeable AMPA receptors and silent synapses in cocaine-conditioned place preference.
EMBO J
2017 36(4): 458-74 [Epub ahead of print: 2016-12-12], IF: 9.643

Budde M, Degner D, Brockmöller J, Schulze TG.
Pharmacogenomic aspects of bipolar disorder: An update.
Eur Neuropsychopharmacol
2017 27(6): 599-609 [Epub ahead of print: 2017-03-23], IF: 4.409

Wehr MC, Hinrichs W, Brzózka MM, Unterbamscheidt T, Herholt A, Wintgens JP, Papiol S, Soto-Bernardini MC, Kravchenko M, Zhang M, Nave K, Wichert SP, Falkai P, Zhang W, Schwab MH, Rossner MJ.
Spironolactone is an antagonist of NRG1-ERBB4 signaling and schizophrenia-relevant endophenotypes in mice.
EMBO Mol Med
2017 9(19): 1448-62 [Epub ahead of print: 2017-07-25], IF: 9.249

Papiol S, Popovic D, Keeser D, Hasan A, Schneider-Axmann T, Degenhardt F, Rossner MJ, Bickeböller H, Schmitt A, Falkai P, Malchow B.
Polygenic risk has an impact on the structural plasticity of hippocampal subfields during aerobic exercise combined with cognitive remediation in multi-episode schizophrenia.
Transl Psychiatry
2017 7(6): e1159 [Epub ahead of print: 2017-06-27], IF: 4.730

Bahari-Javan S, Varbanov H, Halder R, Benito E, Kaurani L, Burkhardt S, Anderson-Schmidt H, Anghelescu I, Budde M, Stilling RM, Costa J, Medina J, Dietrich DE, Figge C, Folkerts H, Gade K, Heilbronner U, Koller M, Konrad C, Nussbeck SY, Scherk H, Spitzer C, Stierl S, Stöckel J, Thiel A, von Hagen M, Zimmermann J, Zitzelsberger A, Schulz S, Schmitt A, Delalle I, Falkai P, Schulze TG, Dityatev A, Sananbenesi F, Fischer A.
HDAC1 links early life stress to schizophrenia-like phenotypes.
Proc Natl Acad Sci U S A
2017 114(23): E4686-E4694 [Epub ahead of print: 2017-05-22], IF: 9.661

Budde M, Forstner AJ, Adorjan K, Schaupp SK, Nöthen MM, Schulze TG.
Genetische Grundlagen der bipolaren Störung.
Nervenarzt
2017 88(7): 755-9 [Epub ahead of print: 0000-00-00], IF: 0.738

2016

Brzózka MM, Rossner MJ, de Hoz L.
Tcf4 transgenic female mice display delayed adaptation in an auditory latent inhibition paradigm.
Eur Arch Psychiatry Clin Neurosci
2016 266(6): 505-12 [Epub ahead of print: 2015-09-24], IF: 3.525

Brzózka MM, Havemann-Reinecke U, Wichert SP, Falkai P, Rossner MJ.
Molecular signatures of psychosocial stress and cognition are modulated by chronic lithium treatment.
Schizophr Bull
2016 42(Suppl 1): S22-33 [Epub ahead of print: 2015-12-28], IF: 8.450

Brzózka MM, Unterbamscheidt T, Schwab MH, Rossner MJ.
OSO paradigm - A rapid behavioral screening method for acute psychosocial stress reactivity in mice.
Neuroscience
2016 314: 1-11 [Epub ahead of print: 2015-11-25], IF: 3.357

Heilbronner U, Gade K, Herms S, Strohmaier J, Lang M, Nöthen MM, Rietschel M, Schulze TG, Degenhardt F.
Effect of copy number variant burden on Global Assessment of Functioning in schizophrenia.
Psychiatr Genet
2016 26(4): 184-5 [Epub ahead of print: 2016-04-25], IF: 1.557

Preusse M, Theis F, Müller N.
miTALOS v2: Analyzing tissue specific microRNA function.
PLOS ONE
2016 11(3): e0151771 [Epub ahead of print: 2016-03-21], IF: 3.234

Papiol S, Fatjó-Vilas M, Schulze TG.
Neurological soft signs in patients with schizophrenia: current knowledge and future perspectives in the post-genomics era.
Translational Developmental Psychiatry
2016 4: 30071 [Epub ahead of print: 2016-07-08], IF: 0.000

Malzahn D, Friedrichs S, Bickeböller H.
Comparing strategies for combined testing of rare and common variants in whole sequence and genome-wide genotype data
BMC Proc
2016 10(Suppl 7): 269-73 [Epub ahead of print: 2016-10-18], IF: 0.000

2015

Schnell C, Shahmoradi A, Wichert SP, Mayerl S, Hagos Y, Heuer H, Rossner MJ, Hülsmann S.
The multispecific thyroid hormone transporter OATP1C1 mediates cell-specific sulforhodamine 101-labeling of hippocampal astrocytes.
Brain Struct Funct
2015 220(1): 193-203 [Epub ahead of print: 2013-10-16], IF: 5.618

Badowska D, Brzózka MM, Chowdhury A, Malzahn D, Rossner MJ.
Data calibration and reduction allows to visualize behavioural profiles of psychosocial influences in mice towards clinical domains.
Eur Arch Psychiatry Clin Neurosci
2015 265(6): 483-96 [Epub ahead of print: 2014-09-19], IF: 3.525

Dwyer DB, Kálmán J, Budde M, Anderson-Schmidt H, Gade K, Heilbronner U, Falkai P, Schulze TG, Koutsouleris N.
Personalised predictions of global functioning in chronic patients across 17 European sites.
SIRS Abstract
2015 : [Epub ahead of print: 0000-00-00], IF: 0.000

Falkai P, Rossner MJ, Schulze TG, Hasan A, Brzózka MM, Malchow B, Honer WG, Schmitt A.
Kraepelin revisited: schizophrenia from degeneration to failed regeneration.
Mol Psychiatry
2015 20(6): 671-6 [Epub ahead of print: 2015-03-31], IF: 13.000

2014

Budde M, Schulze TG.
Neuropsychological correlates of the course of bipolar disorder.
Harvard Rev Psychiatry
2014 22(6): 342-7 [Epub ahead of print: 0000-00-00], IF: 1.727

Nussbeck SY, Skrowny D, O'Donoghue S, Schulze TG, Helbing K.
How to design biospecimen identifiers and integrate relevant functionalities into your biospecimen management system.
Biopreserv Biobank
2014 12(3): 199-205 [Epub ahead of print: 0000-00-00], IF: 1.340

Wolf C, Mohr H, Schneider-Axmann T, Reif A, Wobrock T, Scherk H, Kraft S, Schmitt A, Falkai P, Gruber O.
CACNA1C genotype explains interindividual differences in amygdala volume among patients with schizophrenia.
Eur Arch Psychiatry Clin Neurosci
2014 264(2): 93-102 [Epub ahead of print: 2013-07-24], IF: 3.525

Agarwal A, Zhang M, Unterbamscheidt T, Radyushkin K, Dibaj P, Martins de Souza D, Boretius S, Brzózka MM, Steffens H, Berning S, Teng Z, Gummert MN, Tantra M, Guest PC, Willig KI, Frahm J, Hell S, Bahn S, Rossner MJ, Nave K, Ehrenreich H, Zhang W, Schwab MH.
Dysregulated Expression of Neuregulin-1 by Cortical Pyramidal Neurons Disrupts Synaptic Plasticity.
Cell Rep
2014 8(4): 1130-45 [Epub ahead of print: 2014-08-14], IF: 8.358

Baier PC, Brzózka MM, Shahmoradi A, Reinecke L, Kroos C, Wichert SP, Oster H, Wehr MC, Taneja R, Hirrlinger J, Rossner MJ.
Mice lacking the circadian modulators SHARP1 and SHARP2 display altered sleep and mixed state endophenotypes of psychiatric disorders.
PLOS ONE
2014 9(10): e110310 [Epub ahead of print: 0000-00-00], IF: 3.234

Can A, Schulze TG, Gould TG.
Molecular actions and clinical pharmacogenetics of lithium therapy.
Pharmacol Biochem Behav
2014 123: 13-16 [Epub ahead of print: 2014-02-15], IF: 2.781

Chen H, Malzahn D, Balliu B, Bailey JN.
Testing genetic association with rare and common variants in family data.
Genet Epidemiol
2014 Suppl1: S37-43 [Epub ahead of print: 0000-00-00], IF: 2.597

Malzahn D, Müller-Nurasyid M, Heid IM, Wichmann H, the KORA study group , Bickeböller H.
Controversial association results for INSIG2 on body mass index may be explained by interactions with age and with MC4R.
Eur J Hum Genet
2014 22(10): 1217-24 [Epub ahead of print: 2014-02-12], IF: 4.349

Malzahn D, Friedrichs S, Rosenberger A, Bickeböller H.
Kernel score statistic for dependent data.
BMC Proc
2014 8(Suppl 1): S41 [Epub ahead of print: 0000-00-00], IF: 3.525

Dos Santos Pereira JN, Tadjerpisheh S, Abu Abed M, Saadatmand AR, Weksler B, Romero IA, Couraud PO, Brockmöller J, Tzvetkov M.
The poorly membrane permeable antipsychotic drugs amisulpride and sulpiride are substrates of the organic cation transporters from the SLC22 family.
AAPS J
2014 16(6): 1247-58 [Epub ahead of print: 2014-08-26], IF: 3.799

Quednow BB, Brzózka MM, Rossner MJ.
Transcription factor 4 (TCF4) and schizophrenia: integrating the animal and the human perspective.
Cell Mol Life Sci
2014 71(15): 2815-35 [Epub ahead of print: 2014-01-12], IF: 5.808

Trost S, Diekhof EK, Zvonik K, Lewandowski M, Usher J, Keil M, Zilles D, Falkai P, Dechent P, Gruber O.
Disturbed anterior prefrontal control of the mesolimbic reward system and increased Impulsivity in bipolar disorder.
Neuropsychopharmacology
2014 39(8): 1914-23 [Epub ahead of print: 2014-02-18], IF: 7.048

2013

Anderson-Schmidt H, Adler L, Aly C, Anghelescu I, Bauer M, Baumgärtner J, Becker J, Bianco R, Becker T, Bitter C, Bönsch D, Buckow K, Budde M, Bührig M, Deckert J, Demiroglu SY, Dietrich DE, Dümpelmann M, Engelhardt U, Fallgatter AJ, Feldhaus D, Figge C, Folkerts H, Franz M, Gade K, Gaebel W, Grabe H, Gruber O, Gullatz V, Gusky L, Heilbronner U, Helbing K, Hegerl U, Heinz A, Hensch T, Hiemke C, Jäger M, Jahn-Brodmann A, Juckel G, Kandulski F, Kaschka WP, Kircher T, Koller M, Konrad C, Kornhuber J, Krause M, Krug A, Lee M, Leweke M, Lieb K, Mammes M, Meyer-Lindenberg A, Mühlbacher M, Müller MJ, Nieratschker V, Nierste B, Ohle J, Pfennig A, Pieper M, Quade M, Reich-Erkelenz D, Reif A, Reitt M, Reininghaus B, Reininghaus EZ, Riemenschneider M, Rienhoff O, Roser P, Rujescu D, Schennach R, Scherk H, Schmauss M, Schneider F, Schosser A, Schott BH, Schwab SG, Schwanke J, Skrowny D, Spitzer C, Stierl S, Stöckel J, Stübner S, Thiel A, Volz H, von Hagen M, Walter H, Witt SH, Wobrock T, Zielasek J, Zimmermann J, Zitzelsberger A, Maier W, Falkai P, Rietschel M, Schulze TG.
The "DGPPN-Cohort": a national collaboration initiative by the German Association for Psychiatry and Psychotherapy (DGPPN) for establishing a large-scale cohort of psychiatric patients.
Eur Arch Psychiatry Clin Neurosci
2013 263(8): 695-701 [Epub ahead of print: 2013-04-03], IF: 3.355

Brzózka MM, Rossner MJ.
Deficits in trace fear memory in a mouse model of the schizophrenia risk gene TCF4.
Behav Brain Res
2013 237: 348-356 [Epub ahead of print: 2016-05-02], IF: 3.391

Schwanke J, Rienhoff O, Schulze TG, Nussbeck SY.
Suitability of customer relationship management systems for the management of study participants in biomedical research.
Methods Inf Med
2013 52(4): 340-50 [Epub ahead of print: 2013-06-23], IF: 1.083

Bickeböller H, Thomas DC.
Statistical methods in genetic epidemiology
Handbook of Epidemiology (ed. Ahrens W, Pigeot I), Springer, New York
2013 : [Epub ahead of print: 2017-08-28], IF:

Anderson-Schmidt H, Beltcheva O, Brandon MD, Byrne EM, Diehl EJ, Duncan L, Gonzalez SD, Hannon E, Kantojärvi K, Karagiannidis I, Kos MZ, Kotyuk E, Laufer BI, Mantha K, McGregor NW, Meier SM, Nieratschker V, Spiers H, Squassina A, Thakur GA, Tiwari Y, Viswanath B, Way MJ, Wong CC, O'Shea A, DeLisi LE.
Selected Rapporteur Summaries From the XX World Congress of Psychiatric Genetics, Hamburg, Germany, October 1418, 2012.
Am J Med Genet B Neuropsychiatr Genet
2013 162(2): 96-121 [Epub ahead of print: 2013-01-22], IF: 3.271

2012

Bahari-Javan S, Maddalena A, Kerimoglu C, Wittnam J, Held T, Bähr M, Burkhardt S, Delalle I, Kügler S, Fischer A.
HDAC1 Regulates Fear Extinction in Mice.
J Neurosci
2012 32(15): 5062-73 [Epub ahead of print: 0000-00-00], IF: 7.115

Demiroglu SY, Skrowny D, Quade M, Schwanke J, Budde M, Gullatz V, Reich-Erkelenz D, Jakob JJ, Falkai P, Rienhoff O, Helbing K, Heilbronner U, Schulze TG.
Managing sensitive phenotypic data and biomaterial in large-scale collaborative psychiatric genetic research projects: practical considerations.
Mol Psychiatry
2012 17: 1180-85 [Epub ahead of print: 2012-03-06], IF: 13.668

Tsang AH, Sánchez-Moreno C, Bode B, Rossner MJ, Garaulet M, Oster H.
Tissue-specific interaction of Per1/2 and Dec2 in the regulation of fibroblast circadian rhythms.
J Biol Rhythms
2012 27(6): 478-89 [Epub ahead of print: 2016-05-02], IF: 2.934

Anderson-Schmidt H, Buckow K, Budde M, Deckert J, Demiroglu SY, Falkai P, Gade K, Gaebel W, Grabe H, Gruber O, Gullatz V, Gusky L, Heilbronner U, Helbing K, Juckel G, Kircher T, Konrad C, Krug A, Maier W, Quade M, Reich-Erkelenz D, Reif A, Rienhoff O, Rietschel M, Roser P, Rujescu D, Schott BH, Schwanke J, Skrowny D, Walter H, Witt SH, Zielasek J, Schulze TG.
Die DGPPN-Kohorte als nationale Ressource für vernetzte psychiatrische Forschung datenschutzkonformes Biobanking.
Nervenarzt
2012 3: 406-9 [Epub ahead of print: 0000-00-00], IF: 0.804

2011

Bode B, Shahmoradi A, Rossner MJ, Oster H.
Genetic interaction of Per1 and Dec1/2 in the regulation of circadian locomotor activity.
J Biol Rhythms
2011 26(6): 530-540 [Epub ahead of print: 0000-00-00], IF: 2.934

Bode B, Rossner MJ, Oster H.
Advanced light-entrained activity onsets and restored free-running suprachiasmatic nucleus circadian rhythms in Per2/Dec mutant mice.
Chronobiol Int
2011 28(9): 737-750 [Epub ahead of print: 0000-00-00], IF: 4.028


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