2024-05-28
085_ Characterizing the relevance of stratified genetic risk for cardiometabolic illness in patients with psychosis
Research Question and Aims
Epidemiological studies show that patients with mental illnesses such as schizophrenia or bipolar disorder have a substantially increased risk of cardiometabolic illness that contributes to the marked decrease in life expectancy. Such cardiometabolic conditions are thought to not be a mere side effect of treatment or difference in lifestyle, but to be intrinsically linked to the illnesses’ biology (1). This raises the question of the extent to which the genetic risk of cardiometabolic diseases predisposes individuals with mental disorders to develop such conditions during the course of the illness. In a previous study, imputed gene expression data (generated via the CASTom-iGEx pipeline) in the UK-Biobank cohort was used to identify reproducible subgroups of patients with coronary artery disease (CAD) as well as of patients with schizophrenia. This opens the possibility to test for the relevance of such subgroups in the PsyCourse study, and to assess potential interactions between signatures predictive of CAD and mental illness.
The aim of the present study is to use gene expression data imputed by applying the CASTom-iGEx pipeline on the PsyCourse GWAS data, in order to predict subgroup membership probabilities in patients with mental disorders (and controls, as external control). We intend to test the association between the predicted subgroup probabilities and clinical outcomes, with specific focus on those indicative of CAD. The approach will include both cross-sectional and longitudinal analyses.
I) Cardiometabolic disorders are known to have inflammatory implications (2). Therefore, in our cross-sectional analysis, we aim to investigate whether there is an increased likelihood of inflammatory processes in patients with mental disorders who belong to a subgroup of CAD, compared to those who are not. To test these hypotheses, we will analyze proteomics and lipidomic data to identify and quantify inflammatory markers. II) In the longitudinal analysis, we plan to analyze the effects on clinical course, response to treatment and the development of adverse events during the follow-up time-points in relation to the CAD subgroups. In particular, we want to determine whether patients with mental disorder who belong to a CAD subgroup are more likely to develop metabolic syndrome or experience significant weight gain, especially during treatment with lithium or antidepressants, and whether women with the onset of menopause are at increased risk of developing metabolic syndrome.
Analytic Plan
1. Gene expression data for individuals part of the PsyCourse cohort will be imputed based on GWAS data using the already established CASTom-iGEx pipeline. The imputed data will be adjusted for population stratification effects and potentially other confounding factors. Based on the already established subgroup models determined in UK biobank data, subgroup membership for CAD and schizophrenia subgroups will be predicted in the PsyCourse data.
2. Using the predicted subgroup membership information, we will test for associations with phenotypic data of the PsyCourse cohort, in particular focusing on variables relevant in the cardiometabolic risk context, as well as with regards to psychopathology. This will allow the assessment of whether genetic subgroup risk shows converging associations with CVD-related phenotypes and psychopathological domains. For this analysis, we will use patient clusters identified in a recent version of the PsyCourse dataset, in analogy to the approach of by Dwyer et al (doi: 10.1001/jamapsychiatry.2019.4910.)
3. The predicted subgroups will be analyzed to determine specific metabolic profile changes associated with particular CAD clusters. Genotypic data are utilized for clustering to identify differential methylation or expression. This analysis will explore whether polygenic signals manifest across multiomics levels and correlate with relevant pathways. Additionally, proteomic and lipidomic data will be analysed for markers of inflammatory processes and chronic stress.
4. We will test for interactions between genetic subgroup effects related to CAD and mental illness.
5. The identified associations will then be validated, where possible, in external datasets.
Resources needed
v1_id
v1_stat
v1_center
v1_interv_date
v1_sex
v1_age
v1_marital_stat
v1_partner
v1_no_bio_chld
v1_no_adpt_chld
v1_liv_aln
v1_school
v1_prof_dgr
v1_ed_status
v1_curr_paid_empl
v1_disabl_pens
v1_spec_emp
v1_wrk_abs_pst_5_yrs
v1_cur_work_restr
v1_cntr_brth
v1_cur_psy_trm
v1_outpat_psy_trm
v1_age_1st_out_trm
v1_daypat_inpat_trm
v1_age_1st_inpat_trm
v1_dur_illness
v1_1st_ep
v1_tms_daypat_outpat_trm
v1_cat_daypat_outpat_trm
v1_Antidepressants
v1_Antipsychotics
v1_Mood_stabilizers
v1_Tranquilizers
v1_Other_psychiatric
v1_adv
v1_medchange
v1_lith
v1_lith_prd
v1_fam_hist
v1_height
v1_weight
v1_waist
v1_bmi
v1_chol_trig
v1_hyperten
v1_ang_pec
v1_heart_att
v1_stroke
v1_diabetes
v1_hyperthy
v1_hypothy
v1_asthma
v1_copd
v1_allerg
v1_autoimm
v1_cancer
v1_kid_fail
v1_epilepsy
v1_migraine
v1_parkinson
v1_liv_cir_inf
v1_tbi
v1_beh
v1_eyear
v1_inf
v1_ever_smkd
v1_age_smk
v1_no_cig
v1_alc_pst12_mths
v1_alc_5orm
v1_lftm_alc_dep
v1_evr_ill_drg
v1_pst6_ill_drg
v1_scid_dsm_dx
v1_scid_dsm_dx_cat
v1_scid_age_MDE
v1_scid_no_MDE
v1_scid_age_mania
v1_scid_no_mania
v1_scid_age_hypomania
v1_scid_no_hypomania
v1_scid_ever_halls
v1_scid_ever_delus
v1_scid_ever_psyc
v1_scid_age_fst_psyc
v1_scid_yr_fst_psyc
v1_scid_evr_suic_ide
v1_scid_suic_ide
v1_scid_suic_thght_mth
v1_scid_suic_note_thgts
v1_suic_attmpt
v1_scid_no_suic_attmpt
v1_prep_suic_attp_ord
v1_suic_note_attmpt
v1_age_fst_suic_att
v1_age_sec_suic_att
v1_age_thr_suic_att
v1_panss_p1
v1_panss_p2
v1_panss_p3
v1_panss_p4
v1_panss_p5
v1_panss_p6
v1_panss_p7
v1_panss_n1
v1_panss_n2
v1_panss_n3
v1_panss_n4
v1_panss_n5
v1_panss_n6
v1_panss_n7
v1_panss_g1
v1_panss_g2
v1_panss_g3
v1_panss_g4
v1_panss_g5
v1_panss_g6
v1_panss_g7
v1_panss_g8
v1_panss_g9
v1_panss_g10
v1_panss_g11
v1_panss_g12
v1_panss_g13
v1_panss_g14
v1_panss_g15
v1_panss_g16
v1_panss_sum_pos
v1_panss_sum_neg
v1_panss_sum_gen
v1_panss_sum_tot
v1_idsc_itm1
v1_idsc_itm2
v1_idsc_itm3
v1_idsc_itm4
v1_idsc_itm5
v1_idsc_itm6
v1_idsc_itm7
v1_idsc_itm8
v1_idsc_itm9
v1_idsc_itm9a
v1_idsc_itm9b
v1_idsc_itm10
v1_idsc_itm11
v1_idsc_itm12
v1_idsc_itm13
v1_idsc_itm14
v1_idsc_itm15
v1_idsc_itm16
v1_idsc_itm17
v1_idsc_itm18
v1_idsc_itm19
v1_idsc_itm20
v1_idsc_itm21
v1_idsc_itm22
v1_idsc_itm23
v1_idsc_itm24
v1_idsc_itm25
v1_idsc_itm26
v1_idsc_itm27
v1_idsc_itm28
v1_idsc_itm29
v1_idsc_itm30
v1_idsc_sum
v1_ymrs_itm1
v1_ymrs_itm2
v1_ymrs_itm3
v1_ymrs_itm4
v1_ymrs_itm5
v1_ymrs_itm6
v1_ymrs_itm7
v1_ymrs_itm8
v1_ymrs_itm9
v1_ymrs_itm10
v1_ymrs_itm11
v1_ymrs_sum
v1_cgi_s
v1_gaf
v1_nrpsy_com
v1_nrpsy_lng
v1_nrpsy_mtv
v1_nrpsy_tmt_A_rt
v1_nrpsy_tmt_A_err
v1_nrpsy_tmt_B_rt
v1_nrpsy_tmt_B_err
v1_nrpsy_dgt_sp_frw
v1_nrpsy_dgt_sp_bck
v1_nrpsy_dg_sym
v1_nrpsy_mwtb
v1_med_pst_wk
v1_med_pst_sx_mths
v1_bdi2_itm1
v1_bdi2_itm2
v1_bdi2_itm3
v1_bdi2_itm4
v1_bdi2_itm5
v1_bdi2_itm6
v1_bdi2_itm7
v1_bdi2_itm8
v1_bdi2_itm9
v1_bdi2_itm10
v1_bdi2_itm11
v1_bdi2_itm12
v1_bdi2_itm13
v1_bdi2_itm14
v1_bdi2_itm15
v1_bdi2_itm16
v1_bdi2_itm17
v1_bdi2_itm18
v1_bdi2_itm19
v1_bdi2_itm20
v1_bdi2_itm21
v1_bdi2_sum
v1_leq_A_1A
v1_leq_A_1B
v1_leq_A_2A
v1_leq_A_2B
v1_leq_A_3A
v1_leq_A_3B
v1_leq_A_4A
v1_leq_A_4B
v1_leq_A_5A
v1_leq_A_5B
v1_leq_A_6A
v1_leq_A_6B
v1_leq_A_7A
v1_leq_A_7B
v1_leq_A_8A
v1_leq_A_8B
v1_leq_A_9A
v1_leq_A_9B
v1_big_five_extra
v1_big_five_neuro
v1_big_five_openn
v1_big_five_consc
v1_big_five_agree
v2_age
v2_interv_date
v2_clin_ill_ep_snc_lst
v2_clin_no_ep
v2_clin_fst_ill_ep_man
v2_clin_fst_ill_ep_dep
v2_clin_fst_ill_ep_mx
v2_clin_fst_ill_ep_psy
v2_clin_fst_ill_ep_dur
v2_clin_fst_ill_ep_hsp
v2_clin_fst_ill_ep_hsp_dur
v2_clin_fst_ill_ep_symp_wrs
v2_clin_fst_ill_ep_slf_end
v2_clin_fst_ill_ep_suic
v2_clin_fst_ill_ep_oth_end
v2_clin_fst_ill_ep_med_chg
v2_clin_fst_ill_ep_othr
v2_clin_sec_ill_ep_man
v2_clin_sec_ill_ep_dep
v2_clin_sec_ill_ep_mx
v2_clin_sec_ill_ep_psy
v2_clin_sec_ill_ep_dur
v2_clin_sec_ill_ep_hsp
v2_clin_sec_ill_ep_hsp_dur
v2_clin_sec_ill_ep_symp_wrs
v2_clin_sec_ill_ep_slf_end
v2_clin_sec_ill_ep_suic
v2_clin_sec_ill_ep_oth_end
v2_clin_sec_ill_ep_med_chg
v2_clin_sec_ill_ep_othr
v2_clin_add_oth_hsp
v2_clin_oth_hsp_nmb
v2_clin_oth_hsp_dur
v2_clin_othr_psy_med
v2_cur_psy_trm
v2_con_problems_snc_lst
v2_con_psy_snc_lst
v2_con_no_psy_hosp
v2_con_psy_hosp_dur
v2_con_psy_hosp_why_medchg
v2_con_psy_hosp_why_othr
v2_con_psy_hosp_why_othr_txt
v2_cng_mar_stat
v2_marital_stat
v2_partner
v2_no_bio_chld
v2_no_adpt_chld
v2_chg_hsng
v2_liv_aln
v2_chg_empl_stat
v2_curr_paid_empl
v2_disabl_pens
v2_spec_emp
v2_wrk_abs_pst_6_mths
v2_cur_work_restr
v2_weight
v2_waist
v2_bmi
v2_evnt_prcp_illn
v2_evnt_prcp_illn_txt
v2_suic_ide_snc_lst_vst
v2_scid_suic_ide
v2_scid_suic_thght_mth
v2_scid_suic_note_thgts
v2_suic_attmpt_snc_lst_vst
v2_no_suic_attmpt
v2_prep_suic_attp_ord
v2_suic_note_attmpt
v2_Antidepressants
v2_Antipsychotics
v2_Mood_stabilizers
v2_Tranquilizers
v2_Other_psychiatric
v2_adv
v2_medchange
v2_lith
v2_lith_prd
v2_smk_strt_stp
v2_no_cig
v2_alc_pst6_mths
v2_alc_5orm
v2_pst6_ill_drg
v2_panss_p1
v2_panss_p2
v2_panss_p3
v2_panss_p4
v2_panss_p5
v2_panss_p6
v2_panss_p7
v2_panss_n1
v2_panss_n2
v2_panss_n3
v2_panss_n4
v2_panss_n5
v2_panss_n6
v2_panss_n7
v2_panss_g1
v2_panss_g2
v2_panss_g3
v2_panss_g4
v2_panss_g5
v2_panss_g6
v2_panss_g7
v2_panss_g8
v2_panss_g9
v2_panss_g10
v2_panss_g11
v2_panss_g12
v2_panss_g13
v2_panss_g14
v2_panss_g15
v2_panss_g16
v2_panss_sum_pos
v2_panss_sum_neg
v2_panss_sum_gen
v2_panss_sum_tot
v2_idsc_itm1
v2_idsc_itm2
v2_idsc_itm3
v2_idsc_itm4
v2_idsc_itm5
v2_idsc_itm6
v2_idsc_itm7
v2_idsc_itm8
v2_idsc_itm9
v2_idsc_itm9a
v2_idsc_itm9b
v2_idsc_itm10
v2_idsc_itm11
v2_idsc_itm12
v2_idsc_itm13
v2_idsc_itm14
v2_idsc_itm15
v2_idsc_itm16
v2_idsc_itm17
v2_idsc_itm18
v2_idsc_itm19
v2_idsc_itm20
v2_idsc_itm21
v2_idsc_itm22
v2_idsc_itm23
v2_idsc_itm24
v2_idsc_itm25
v2_idsc_itm26
v2_idsc_itm27
v2_idsc_itm28
v2_idsc_itm29
v2_idsc_itm30
v2_idsc_sum
v2_ymrs_itm1
v2_ymrs_itm2
v2_ymrs_itm3
v2_ymrs_itm4
v2_ymrs_itm5
v2_ymrs_itm6
v2_ymrs_itm7
v2_ymrs_itm8
v2_ymrs_itm9
v2_ymrs_itm10
v2_ymrs_itm11
v2_ymrs_sum
v2_cgi_s
v2_cgi_c
v2_gaf
v2_nrpsy_com
v2_nrpsy_lng
v2_nrpsy_mtv
v2_nrpsy_vlmt_check
v2_nrpsy_vlmt_corr
v2_nrpsy_vlmt_lss_d
v2_nrpsy_vlmt_lss_t
v2_nrpsy_vlmt_rec
v2_nrpsy_tmt_A_rt
v2_nrpsy_tmt_A_err
v2_nrpsy_tmt_B_rt
v2_nrpsy_tmt_B_err
v2_nrpsy_dgt_sp_frw
v2_nrpsy_dgt_sp_bck
v2_nrpsy_dg_sym
v2_med_pst_wk
v2_med_pst_sx_mths
v2_bdi2_itm1
v2_bdi2_itm2
v2_bdi2_itm3
v2_bdi2_itm4
v2_bdi2_itm5
v2_bdi2_itm6
v2_bdi2_itm7
v2_bdi2_itm8
v2_bdi2_itm9
v2_bdi2_itm10
v2_bdi2_itm11
v2_bdi2_itm12
v2_bdi2_itm13
v2_bdi2_itm14
v2_bdi2_itm15
v2_bdi2_itm16
v2_bdi2_itm17
v2_bdi2_itm18
v2_bdi2_itm19
v2_bdi2_itm20
v2_bdi2_itm21
v2_bdi2_sum
v2_leq_A_1A
v2_leq_A_1B
v2_leq_A_2A
v2_leq_A_2B
v2_leq_A_3A
v2_leq_A_3B
v2_leq_A_4A
v2_leq_A_4B
v2_leq_A_5A
v2_leq_A_5B
v2_leq_A_6A
v2_leq_A_6B
v2_leq_A_7A
v2_leq_A_7B
v2_leq_A_8A
v2_leq_A_8B
v2_leq_A_9A
v2_leq_A_9B
v3_age
v3_interv_date
v3_clin_ill_ep_snc_lst
v3_clin_no_ep
v3_clin_fst_ill_ep_man
v3_clin_fst_ill_ep_dep
v3_clin_fst_ill_ep_mx
v3_clin_fst_ill_ep_psy
v3_clin_fst_ill_ep_dur
v3_clin_fst_ill_ep_hsp
v3_clin_fst_ill_ep_hsp_dur
v3_clin_fst_ill_ep_symp_wrs
v3_clin_fst_ill_ep_slf_end
v3_clin_fst_ill_ep_suic
v3_clin_fst_ill_ep_oth_end
v3_clin_fst_ill_ep_med_chg
v3_clin_fst_ill_ep_othr
v3_clin_sec_ill_ep_man
v3_clin_sec_ill_ep_dep
v3_clin_sec_ill_ep_mx
v3_clin_sec_ill_ep_psy
v3_clin_sec_ill_ep_dur
v3_clin_sec_ill_ep_hsp
v3_clin_sec_ill_ep_hsp_dur
v3_clin_sec_ill_ep_symp_wrs
v3_clin_sec_ill_ep_slf_end
v3_clin_sec_ill_ep_suic
v3_clin_sec_ill_ep_oth_end
v3_clin_sec_ill_ep_med_chg
v3_clin_sec_ill_ep_othr
v3_clin_add_oth_hsp
v3_clin_oth_hsp_nmb
v3_clin_oth_hsp_dur
v3_clin_othr_psy_med
v3_cur_psy_trm
v3_con_problems_snc_lst
v3_con_psy_snc_lst
v3_con_no_psy_hosp
v3_con_psy_hosp_dur
v3_con_psy_hosp_why_medchg
v3_con_psy_hosp_why_othr
v3_con_psy_hosp_why_othr_txt
v3_cng_mar_stat
v3_marital_stat
v3_partner
v3_no_bio_chld
v3_no_adpt_chld
v3_chg_hsng
v3_liv_aln
v3_chg_empl_stat
v3_curr_paid_empl
v3_disabl_pens
v3_spec_emp
v3_wrk_abs_pst_6_mths
v3_cur_work_restr
v3_weight
v3_bmi
v3_waist
v3_suic_ide_snc_lst_vst
v3_scid_suic_ide
v3_scid_suic_thght_mth
v3_scid_suic_note_thgts
v3_suic_attmpt_snc_lst_vst
v3_no_suic_attmpt
v3_prep_suic_attp_ord
v3_suic_note_attmpt
v3_Antidepressants
v3_Antipsychotics
v3_Mood_stabilizers
v3_Tranquilizers
v3_Other_psychiatric
v3_adv
v3_medchange
v3_lith
v3_lith_prd
v3_smk_strt_stp
v3_no_cig
v3_alc_pst6_mths
v3_alc_5orm
v3_pst6_ill_drg
v3_panss_p1
v3_panss_p2
v3_panss_p3
v3_panss_p4
v3_panss_p5
v3_panss_p6
v3_panss_p7
v3_panss_n1
v3_panss_n2
v3_panss_n3
v3_panss_n4
v3_panss_n5
v3_panss_n6
v3_panss_n7
v3_panss_g1
v3_panss_g2
v3_panss_g3
v3_panss_g4
v3_panss_g5
v3_panss_g6
v3_panss_g7
v3_panss_g8
v3_panss_g9
v3_panss_g10
v3_panss_g11
v3_panss_g12
v3_panss_g13
v3_panss_g14
v3_panss_g15
v3_panss_g16
v3_panss_sum_pos
v3_panss_sum_neg
v3_panss_sum_gen
v3_panss_sum_tot
v3_idsc_itm1
v3_idsc_itm2
v3_idsc_itm3
v3_idsc_itm4
v3_idsc_itm5
v3_idsc_itm6
v3_idsc_itm7
v3_idsc_itm8
v3_idsc_itm9
v3_idsc_itm9a
v3_idsc_itm9b
v3_idsc_itm10
v3_idsc_itm11
v3_idsc_itm12
v3_idsc_itm13
v3_idsc_itm14
v3_idsc_itm15
v3_idsc_itm16
v3_idsc_itm17
v3_idsc_itm18
v3_idsc_itm19
v3_idsc_itm20
v3_idsc_itm21
v3_idsc_itm22
v3_idsc_itm23
v3_idsc_itm24
v3_idsc_itm25
v3_idsc_itm26
v3_idsc_itm27
v3_idsc_itm28
v3_idsc_itm29
v3_idsc_itm30
v3_idsc_sum
v3_ymrs_itm1
v3_ymrs_itm2
v3_ymrs_itm3
v3_ymrs_itm4
v3_ymrs_itm5
v3_ymrs_itm6
v3_ymrs_itm7
v3_ymrs_itm8
v3_ymrs_itm9
v3_ymrs_itm10
v3_ymrs_itm11
v3_ymrs_sum
v3_cgi_s
v3_cgi_c
v3_gaf
v3_nrpsy_com
v3_nrpsy_lng
v3_nrpsy_mtv
v3_nrpsy_vlmt_check
v3_nrpsy_vlmt_corr
v3_nrpsy_vlmt_lss_d
v3_nrpsy_vlmt_lss_t
v3_nrpsy_vlmt_rec
v3_nrpsy_tmt_A_rt
v3_nrpsy_tmt_A_err
v3_nrpsy_tmt_B_rt
v3_nrpsy_tmt_B_err
v3_nrpsy_dgt_sp_frw
v3_nrpsy_dgt_sp_bck
v3_nrpsy_dg_sym
v3_cts_1
v3_cts_2
v3_cts_3
v3_cts_4
v3_cts_5
v3_cts_els_dic
v3_cts_1_dic
v3_cts_2_dic
v3_cts_3_dic
v3_cts_4_dic
v3_cts_5_dic
v3_med_pst_wk
v3_med_pst_sx_mths
v3_bdi2_itm1
v3_bdi2_itm2
v3_bdi2_itm3
v3_bdi2_itm4
v3_bdi2_itm5
v3_bdi2_itm6
v3_bdi2_itm7
v3_bdi2_itm8
v3_bdi2_itm9
v3_bdi2_itm10
v3_bdi2_itm11
v3_bdi2_itm12
v3_bdi2_itm13
v3_bdi2_itm14
v3_bdi2_itm15
v3_bdi2_itm16
v3_bdi2_itm17
v3_bdi2_itm18
v3_bdi2_itm19
v3_bdi2_itm20
v3_bdi2_itm21
v3_bdi2_sum
v3_mss_sum
v3_leq_A_1A
v3_leq_A_1B
v3_leq_A_2A
v3_leq_A_2B
v3_leq_A_3A
v3_leq_A_3B
v3_leq_A_4A
v3_leq_A_4B
v3_leq_A_5A
v3_leq_A_5B
v3_leq_A_6A
v3_leq_A_6B
v3_leq_A_7A
v3_leq_A_7B
v3_leq_A_8A
v3_leq_A_8B
v3_leq_A_9A
v3_leq_A_9B
v4_age
v4_interv_date
v4_clin_ill_ep_snc_lst
v4_clin_no_ep
v4_clin_fst_ill_ep_man
v4_clin_fst_ill_ep_dep
v4_clin_fst_ill_ep_mx
v4_clin_fst_ill_ep_psy
v4_clin_fst_ill_ep_dur
v4_clin_fst_ill_ep_hsp
v4_clin_fst_ill_ep_hsp_dur
v4_clin_fst_ill_ep_symp_wrs
v4_clin_fst_ill_ep_slf_end
v4_clin_fst_ill_ep_suic
v4_clin_fst_ill_ep_oth_end
v4_clin_fst_ill_ep_med_chg
v4_clin_fst_ill_ep_othr
v4_clin_sec_ill_ep_man
v4_clin_sec_ill_ep_dep
v4_clin_sec_ill_ep_mx
v4_clin_sec_ill_ep_psy
v4_clin_sec_ill_ep_dur
v4_clin_sec_ill_ep_hsp
v4_clin_sec_ill_ep_hsp_dur
v4_clin_sec_ill_ep_symp_wrs
v4_clin_sec_ill_ep_slf_end
v4_clin_sec_ill_ep_suic
v4_clin_sec_ill_ep_oth_end
v4_clin_sec_ill_ep_med_chg
v4_clin_sec_ill_ep_othr
v4_clin_add_oth_hsp
v4_clin_oth_hsp_nmb
v4_clin_oth_hsp_dur
v4_clin_othr_psy_med
v4_cur_psy_trm
v4_con_problems_snc_lst
v4_con_psy_snc_lst
v4_con_no_psy_hosp
v4_con_psy_hosp_dur
v4_con_psy_hosp_why_medchg
v4_con_psy_hosp_why_othr
v4_con_psy_hosp_why_othr_txt
v4_cng_mar_stat
v4_marital_stat
v4_partner
v4_no_bio_chld
v4_no_adpt_chld
v4_stp_chld
v4_chg_hsng
v4_liv_aln
v4_chg_empl_stat
v4_curr_paid_empl
v4_disabl_pens
v4_spec_emp
v4_wrk_abs_pst_6_mths
v4_cur_work_restr
v4_weight
v4_bmi
v4_waist
v4_opcrit
v4_suic_ide_snc_lst_vst
v4_scid_suic_ide
v4_scid_suic_thght_mth
v4_scid_suic_note_thgts
v4_suic_attmpt_snc_lst_vst
v4_no_suic_attmpt
v4_prep_suic_attp_ord
v4_suic_note_attmpt
v4_Antidepressants
v4_Antipsychotics
v4_Mood_stabilizers
v4_Tranquilizers
v4_Other_psychiatric
v4_adv
v4_medchange
v4_lith
v4_lith_prd
v4_alda_A
v4_alda_B1
v4_alda_B2
v4_alda_B3
v4_alda_B4
v4_alda_B5
v4_smk_strt_stp
v4_no_cig
v4_alc_pst6_mths
v4_alc_5orm
v4_pst6_ill_drg
v4_panss_p1
v4_panss_p2
v4_panss_p3
v4_panss_p4
v4_panss_p5
v4_panss_p6
v4_panss_p7
v4_panss_n1
v4_panss_n2
v4_panss_n3
v4_panss_n4
v4_panss_n5
v4_panss_n6
v4_panss_n7
v4_panss_g1
v4_panss_g2
v4_panss_g3
v4_panss_g4
v4_panss_g5
v4_panss_g6
v4_panss_g7
v4_panss_g8
v4_panss_g9
v4_panss_g10
v4_panss_g11
v4_panss_g12
v4_panss_g13
v4_panss_g14
v4_panss_g15
v4_panss_g16
v4_panss_sum_pos
v4_panss_sum_neg
v4_panss_sum_gen
v4_panss_sum_tot
v4_idsc_itm1
v4_idsc_itm2
v4_idsc_itm3
v4_idsc_itm4
v4_idsc_itm5
v4_idsc_itm6
v4_idsc_itm7
v4_idsc_itm8
v4_idsc_itm9
v4_idsc_itm9a
v4_idsc_itm9b
v4_idsc_itm10
v4_idsc_itm11
v4_idsc_itm12
v4_idsc_itm13
v4_idsc_itm14
v4_idsc_itm15
v4_idsc_itm16
v4_idsc_itm17
v4_idsc_itm18
v4_idsc_itm19
v4_idsc_itm20
v4_idsc_itm21
v4_idsc_itm22
v4_idsc_itm23
v4_idsc_itm24
v4_idsc_itm25
v4_idsc_itm26
v4_idsc_itm27
v4_idsc_itm28
v4_idsc_itm29
v4_idsc_itm30
v4_idsc_sum
v4_ymrs_itm1
v4_ymrs_itm2
v4_ymrs_itm3
v4_ymrs_itm4
v4_ymrs_itm5
v4_ymrs_itm6
v4_ymrs_itm7
v4_ymrs_itm8
v4_ymrs_itm9
v4_ymrs_itm10
v4_ymrs_itm11
v4_ymrs_sum
v4_cgi_s
v4_cgi_c
v4_gaf
v4_nrpsy_com
v4_nrpsy_lng
v4_nrpsy_mtv
v4_nrpsy_vlmt_check
v4_nrpsy_vlmt_corr
v4_nrpsy_vlmt_lss_d
v4_nrpsy_vlmt_lss_t
v4_nrpsy_vlmt_rec
v4_nrpsy_tmt_A_rt
v4_nrpsy_tmt_A_err
v4_nrpsy_tmt_B_rt
v4_nrpsy_tmt_B_err
v4_nrpsy_dgt_sp_frw
v4_nrpsy_dgt_sp_bck
v4_nrpsy_dg_sym
v4_med_pst_wk
v4_med_pst_sx_mths
v4_bdi2_itm1
v4_bdi2_itm2
v4_bdi2_itm3
v4_bdi2_itm4
v4_bdi2_itm5
v4_bdi2_itm6
v4_bdi2_itm7
v4_bdi2_itm8
v4_bdi2_itm9
v4_bdi2_itm10
v4_bdi2_itm11
v4_bdi2_itm12
v4_bdi2_itm13
v4_bdi2_itm14
v4_bdi2_itm15
v4_bdi2_itm16
v4_bdi2_itm17
v4_bdi2_itm18
v4_bdi2_itm19
v4_bdi2_itm20
v4_bdi2_itm21
v4_bdi2_sum
v4_leq_A_1A
v4_leq_A_1B
v4_leq_A_2A
v4_leq_A_2B
v4_leq_A_3A
v4_leq_A_3B
v4_leq_A_4A
v4_leq_A_4B
v4_leq_A_5A
v4_leq_A_5B
v4_leq_A_6A
v4_leq_A_6B
v4_leq_A_7A
v4_leq_A_7B
v4_leq_A_8A
v4_leq_A_8B
v4_leq_A_9A
v4_leq_A_9B
gsa_id
v1_prot_id
v2_prot_id
v3_prot_id
v4_prot_id
v1_lip_id
v2_lip_id
v3_lip_id
v4_lip_id