060_ Stability of employment and relationship status over time in patients from the affective-to-psychotic spectrum
Research Question and Aims
Employment and relationship status are major indicators for social integration and rank among the most desired goals by patients (Emsley et al., 2011; Heering et al., 2015; Lambert et al., 2010). Employment is shown to decline after the diagnosis of schizophrenia (SZ), bipolar disorder (BPD) or depression (Christensen et al., 2021). Meta-analysis of follow-up studies shows, that the relationship status often changes after diagnosis of first episode psychosis (Ajnakina et al., 2021). Low satisfaction with occupation and relationship status affect quality of life and might therefore need special attention (Nyer et al., 2010; Sylvia et al., 2017).
This project will investigate the stability of employment and relationship over time within the PsyCourse study. We want to investigate if, social integration is mediated by the diagnostic subgroups over time or based on the symptomatic burden of the disease.
The hypothesis is that patients once diagnosed with a disorder from the affective to psychotic spectrum remain in their state of employment and relationship status. We hypothesize that differences are based on the diagnostic subgroup, and these are better explained by the symptomatic burden than the diagnostic subgroup itself.
1. We hypothesize that overall, neither employment nor relationship status will change over time.
2. We hypothesize that the changes in employment and/or relationship status are dependent on the diagnostic group ("affective" vs. "psychotic") (significant diagnosis x time interaction effect).
3. We hypothesize that these changes are better explained by the symptomatic burden (measured by GAF), than the diagnostic group ("affective" vs. "psychotic") alone.
Longitudinal Data from all PsyCourse participants (younger than 65 years old) will be used.
The analyses will be performed cross-diagnostically and at four timepoints in the following diagnostic subgroups: psychotic disorder and affective disorder as well as in the healthy control group (as control group).
employment and relationship status
Diagnostic group (psychotic or affective) and symptomatic burden measured by GAF
Multistate model with two transient states each: 1. employment status and dx group ; 2. relationship status and dx group ; 3. employment status and symptomatic burden ; 4. relationship status and symptomatic burden.
comparison of model 1 vs. 3 and model 2 vs. 4 compared via Akaike's information criterion (AIC)