056_ Investigating the association of plasma lipidomic profile with cognitive performance in the PsyCourse Study
Research Question and Aims
Lipidomics, as a branch of metabolomics is defined as "the full characterization of lipid molecular species and of their biological roles with respect to expression of proteins involved in lipid metabolism and function, including gene regulation" (1). Understanding the diversity and specificity of lipid species and their changes in plasma of neuropsychiatric disorders can assist in the discovery of possible biological markers for human brain diseases (2) and in furthering our understanding of the pathophysiology underlying mental illnesses. Lipids hold important yet under-regarded roles in brain physiology such as synaptic function and neuronal membrane composition. The potential role of lipids in physiology and as biological marker can be clarified by assessing the probable association between circulating lipid species and cross-sectional and longitudinal neurocognitive performance to identify defects in regulation of biochemical pathways and molecular networks. In this regard, we hypothesize that alterations of plasma lipid species are associated with neurocognitive performance and changes in plasma lipid profiles may play a role in cognitive function in individuals with psychiatric disorders in the PsyCourse Study.
Association analyses & statistical approach
Using the plasma lipidomic data of individuals of the PsyCourse Study, we will investigate the association between circulating plasma lipid species with cross-sectional approach as well as longitudinal changes in neurocognitive performance. The analyses will be adjusted for age, sex, diagnosis, duration of illness, body mass index, educational attainment, medication use, PCAs, and other relevant covariates in the context of repeated measures/linear mixed models.
Raw data on medication and drug use
210908_v5.0_psycourse_clin_raw_ill_drg_(visit1 to visit4).RData
210908_v5.0_psycourse_clin_raw_med_(visit1 to visit4).RData
210908_v5.0_psycourse_con_raw_ill_drg_(visit1 to visit4).RData
210908_v5.0_psycourse_con_raw_med_(visit1 to visit4).RData
Body mass index (BMI)
Plasma lipidomics data for all individuals whose lipidomics data is available from the PsyCourse Study.