047_ Predominant polarity: investigating the effect of manic episodes in cognitive performance of patients with bipolar disorder
Research Question and Aims
Bipolar disorder is a chronic mood disorder with episodic progress and high relapse rate. Patients with bipolar disorder show cognitive deficits regardless of the phase of the illness. The concept of predominant polarity (PP) is defined as presenting more symptoms of one polarity, which could represent an important specifier for bipolar disorder, establishing distinct groups of patients and providing a potential tool for tailored treatment. Although there is a lack of consensus on a unifying definition, previous studies have defined PP as one polarity (either depression or mania episodes) occurring during at least two-thirds of the lifetime. Different studies suggest that manic episodes may be associated to a higher number of hospitalizations, suicide attempts, episodes with psychotic symptoms and the presence of higher cognitive impairment in bipolar disorder, especially in verbal memory.
The objective of the study is to investigate the relationship between the PP specifier and the cognitive dysfunction often found in patients with bipolar disorder. As far as we know, only one study addressed the relationship between PP and cognitive performance with a relatively small sample size. Considering the association of manic episodes to cognitive impairment and the higher frequency of manic episodes in patients with manic PP we hypothesize that patients with a manic PP will show greater cognitive deficits than those with a depressive PP.
Considering the association of manic episodes to cognitive impairment and the higher frequency of manic episodes in patients with manic PP we hypothesize that patients with a manic PP will show greater cognitive deficits than those with a depressive PP.
Analysis will include the PsyCourse samples (patients) and the Barcelona Sample (patients). Using these data we will investigate the association of PP with cognitive variables. First, the whole sample will be divided in three groups according to the predominant polarity (depressive, manic or indeterminate). Potential differences between groups in sociodemographic, clinical and cognitive variables will be analyzed by means of linear mixed models with centre as random effect. A second series of correlations analyses will be run to investigate the association of cognitive variables and the number of the different type of episodes.