2020-05-04

030_ Phenotypic variability of cognitive, psychosocial functioning, and symptomatic data in the PsyCourse cohort.

Research Question and Aims

A focus of this proposal is the systematic investigation of phenotypic variability in cognition, psychopathology, and psychosocial impairment in the PsyCourse cohort. This issue is raised in the KFO241 grant application, WP5. We will use the results of this proposal in the KFO241/PsyCourse grant report due in summer, but depending on the results aim at an independent journal publication. The main question is how constant phenotypes assessed in controls stay over the 18 months assessment period with respect to both variability and trend. Furthermore, we would like to compare this putative longitudinal constant behavior and/or variability to that of cases. For this purpose, we will use where appropriate linear mixed models, but also methods independent of such distributional assumptions like the rang-based longitudinal nonparametric test (LNTP, PMID: 20568282), previously extended by our group to the context of genetic epidemiology, and successfully applied to analyze other cohorts (e.g. Psychosis, PMID: 26475575).

Analytic Plan

First we have selected several phenotypes (see list below) in order to focus this investigation. We will start with descriptive statistics regarding variability and course and missingness of assessments. We will then use LNPT and linear mixed models to assess time effects (analyses of control participants) and time*diagnosis (comparison of cases and controls). A special emphasis will be given to handling of age classes and varying time-points in the LNPT (KFO241, WP5, aims 2 and 4). Correction for multiple testing will not be applied to between phenotypes for those analyses using only controls, as it is important to identify potential non-constant and variable patterns in controls that might create unexpected noise for comparisons between cases and controls. Thus this part has a more explorative nature (consider also the limited sample size of roughly 300 controls). Comparisons with cases will be carried out with appropriate corrections.

Resources needed

Participant identity column v1_id
Clinical/Control Status v1_stat
Date of interview v1_interv_date, v2_interv_date, v3_interv_date, and v4_interv_date
Recruitment center v1_center
GWAS analysis ID gwas_id

Demographic information
Sex v1_sex
Age at first interview v1_age
Education v1_ed_status

Ethnicity
Country of birth v1_cntr_brth
Country of birth mother v1_cntr_brth_m
Country of birth father v1_cntr_brth_f

Psychiatric history
Medication v1_Antidepressants, v1_Antipsychotics, v1_Mood_stabilizers, v1_Tranquilizers and v1_Other_psychiatric
Family history of psychiatric illness v1_fam_hist

Substance abuse:
Alcohol v1_lftm_alc_dep
Illicit drugs v1_evr_ill_drg and v1_evr_hvy_usr

Cognitive variables
Trail-Making-Test:
v1_nrpsy_tmt_A_rt
v2_nrpsy_tmt_A_rt, v3_nrpsy_tmt_A_rt
v4_nrpsy_tmt_A_rt and v1_nrpsy_tmt_B_rt
v2_nrpsy_tmt_B_rt
v3_nrpsy_tmt_B_rt
v4_nrpsy_tmt_B_rt

Zahlenspanne:
v1_nrpsy_dgt_sp_frw
v2_nrpsy_dgt_sp_frw
v3_nrpsy_dgt_sp_frw
v4_nrpsy_dgt_sp_frw and v1_nrpsy_dgt_sp_bck
v2_nrpsy_dgt_sp_bck, v3_nrpsy_dgt_sp_bck
v4_nrpsy_dgt_sp_bck

Zahlen-Symbol-Test:
v1_nrpsy_dg_sym
v2_nrpsy_dg_sym
v3_nrpsy_dg_sym and v4_nrpsy_dg_sym

Verbaler Lern und Merkfähigkeitstest (nur dreimal erhoben)
v2_nrpsy_vlmt_corr
v3_nrpsy_vlmt_corr
v4_nrpsy_vlmt_corr and v2_nrpsy_vlmt_lss_d
v3_nrpsy_vlmt_lss_d, v4_nrpsy_vlmt_lss_d and v2_nrpsy_vlmt_lss_t
v3_nrpsy_vlmt_lss_t
v4_nrpsy_vlmt_lss_t and v2_nrpsy_vlmt_lss_rec
v3_nrpsy_vlmt_lss_rec
v4_nrpsy_vlmt_lss_rec

Psychiatric rating scales
GAF:
v1_gaf
v2_gaf
v3_gaf
v4_gaf

PANSS Subskalen (Positive SZ, Negative SZ, und "general psychopathology" Subskala):
v1_panss_sum_pos
v2_panss_sum_pos
v3_panss_sum_pos
v4_panss_sum_pos and v1_panss_sum_neg
v2_panss_sum_neg
v3_panss_sum_neg
v4_panss_sum_neg and v1_panss_sum_gen
v2_panss_sum_gen
v3_panss_sum_gen
v4_panss_sum_gen
IDS-C (Depressive Symptome):
v1_idsc_sum
v2_idsc_sum
v3_idsc_sum and v4_idsc_sum

YMRS (Manie Symptome):
v1_ymrs_sum
v2_ymrs_sum
v3_ymrs_sum and v4_ymrs_sum

Questionnaires
BDI2 (Depression):>v1_bdi2_sum
v2_bdi2_sum
v3_bdi2_sum and v4_bdi2_sum

Manie-Selbstbeurteilungsskala:
v1_mss_sum
v2_mss_sum
v3_mss_sum and v4_mss_sum